' 
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.3
USERS' SCORE
Good
Based on 1 Review
8.3
Supplement Facts
Serving Size: 1 Vegetable Capsule
Amount Per Serving
%DV
Iron (as iron bisglycinate chelate†)
25 mg
139%
Top Medical Research Studies
9
Iron nanoparticle imaging efficacy
A subtype specific probe for targeted magnetic resonance imaging of M2 tumor-associated macrophages in brain tumors.
High relevance to brain tumor imaging
We explored the potential of using a specific type of iron nanoparticle to target and image a distinct group of immune cells known as M2 tumor-associated macrophages (TAMs) in brain tumors. These M2 TAMs can promote tumor growth and understanding their behavior could offer insights for better cancer treatments.
In our research, we developed a unique magnetic resonance imaging (MRI) probe composed of ultrafine iron oxide nanoparticles, which are small enough to avoid non-specific action in the body. We included a special peptide that actively seeks out M2 TAMs, allowing us to visualize them more clearly in mouse models of glioblastoma, a common and aggressive type of brain cancer.
The results were promising. The targeted nanoparticles showed a significant increase in accumulation within the tumors compared to standard nanoparticle formulations. This means that the M2-specific MRI probe provided a noticeable contrast in imaging, helping us differentiate areas of interest in the brain tumor environment better than conventional methods.
By demonstrating how effectively these iron nanoparticles can target specific immune cells, our study lays the groundwork for future research surrounding their use in cancer diagnostics and possibly in therapy. This could lead to improved strategies for tracking and altering the tumor environment as cancer progresses.
In our research, we developed a unique magnetic resonance imaging (MRI) probe composed of ultrafine iron oxide nanoparticles, which are small enough to avoid non-specific action in the body. We included a special peptide that actively seeks out M2 TAMs, allowing us to visualize them more clearly in mouse models of glioblastoma, a common and aggressive type of brain cancer.
The results were promising. The targeted nanoparticles showed a significant increase in accumulation within the tumors compared to standard nanoparticle formulations. This means that the M2-specific MRI probe provided a noticeable contrast in imaging, helping us differentiate areas of interest in the brain tumor environment better than conventional methods.
By demonstrating how effectively these iron nanoparticles can target specific immune cells, our study lays the groundwork for future research surrounding their use in cancer diagnostics and possibly in therapy. This could lead to improved strategies for tracking and altering the tumor environment as cancer progresses.
Read More
8
Innovative glioblastoma treatment approach
Metabolically-Driven Active Targeting of Magnetic Nanoparticles Functionalized with Glucuronic Acid to Glioblastoma: Application to MRI-Tracked Magnetic Hyperthermia Therapy.
Direct investigation of iron use
Our exploration of glioblastoma treatment revealed an innovative way to focus on this challenging brain tumor using iron-based nanoparticles. By functionalizing Iron Oxide Nanoparticles (IONPs) with glucuronic acid, we harnessed the natural glucose transporters that are often overactive in glioblastoma cells. This strategy allows for a direct pathway into the tumor, especially when we induce mild hypoglycemia to enhance the process.
The results of our preclinical study were promising, as we observed significant delays in tumor growth following treatment. The IONPs not only served to target the tumors effectively but also acted as agents for magnetic hyperthermia therapy, which provides an added layer of treatment. Using MRI tracking, we ensured that the procedure was not only effective but also precise, minimizing complications.
This approach shows great potential for developing new ways to tackle glioblastoma, marking a significant step forward in brain cancer treatment. The combination of advanced targeting methods and hyperthermia opens new doors for improved therapies, hopefully leading to more successful outcomes for patients.
The results of our preclinical study were promising, as we observed significant delays in tumor growth following treatment. The IONPs not only served to target the tumors effectively but also acted as agents for magnetic hyperthermia therapy, which provides an added layer of treatment. Using MRI tracking, we ensured that the procedure was not only effective but also precise, minimizing complications.
This approach shows great potential for developing new ways to tackle glioblastoma, marking a significant step forward in brain cancer treatment. The combination of advanced targeting methods and hyperthermia opens new doors for improved therapies, hopefully leading to more successful outcomes for patients.
Read More
8
Iron influences tumor cell movement
Iron promotes isocitrate dehydrogenase mutant glioma cell motility.
High relevance to tumor behavior
We explored the relationship between iron levels and glioma cells, particularly those with isocitrate dehydrogenase (IDH) mutations. Our investigation focused on how these mutations affect iron metabolism and influence tumor growth and movement.
We found that glioma cells with IDH mutations, specifically the U87 cell line, grow significantly faster than their wild-type counterparts. This faster growth is associated with increased expression of transferrin receptors, which help import iron into the cells. Interestingly, this enhanced capacity for iron uptake and manipulation is also retained in live models, suggesting a strong link between iron and tumor behavior.
Biomechanically, modified U87 cells were found to be less stiff, giving them greater fluidity. When we supplemented these cells with ferrous ammonium sulfate—a source of iron—they became even more motile. This finding sheds light on how higher iron content may act as a driving force behind the progression of brain tumors through changes in cell movement characteristics.
Overall, our research indicates that iron metabolism significantly impacts glioma behavior, especially in the context of IDH mutations, presenting a potential area for future therapeutic approaches.
We found that glioma cells with IDH mutations, specifically the U87 cell line, grow significantly faster than their wild-type counterparts. This faster growth is associated with increased expression of transferrin receptors, which help import iron into the cells. Interestingly, this enhanced capacity for iron uptake and manipulation is also retained in live models, suggesting a strong link between iron and tumor behavior.
Biomechanically, modified U87 cells were found to be less stiff, giving them greater fluidity. When we supplemented these cells with ferrous ammonium sulfate—a source of iron—they became even more motile. This finding sheds light on how higher iron content may act as a driving force behind the progression of brain tumors through changes in cell movement characteristics.
Overall, our research indicates that iron metabolism significantly impacts glioma behavior, especially in the context of IDH mutations, presenting a potential area for future therapeutic approaches.
Read More
Most Useful Reviews
6.3
Reduced symptoms
I developed restless legs syndrome (RLS) about 10 years ago and started taking it due to its relation to iron deficiency in the brain. My symptoms have since eased, but I haven't used it again as the lid was difficult to open, and I broke it.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.3
9
Iron nanoparticle imaging efficacy
A subtype specific probe for targeted magnetic resonance imaging of M2 tumor-associated macrophages in brain tumors.
High relevance to brain tumor imaging
We explored the potential of using a specific type of iron nanoparticle to target and image a distinct group of immune cells known as M2 tumor-associated macrophages (TAMs) in brain tumors. These M2 TAMs can promote tumor growth and understanding their behavior could offer insights for better cancer treatments.
In our research, we developed a unique magnetic resonance imaging (MRI) probe composed of ultrafine iron oxide nanoparticles, which are small enough to avoid non-specific action in the body. We included a special peptide that actively seeks out M2 TAMs, allowing us to visualize them more clearly in mouse models of glioblastoma, a common and aggressive type of brain cancer.
The results were promising. The targeted nanoparticles showed a significant increase in accumulation within the tumors compared to standard nanoparticle formulations. This means that the M2-specific MRI probe provided a noticeable contrast in imaging, helping us differentiate areas of interest in the brain tumor environment better than conventional methods.
By demonstrating how effectively these iron nanoparticles can target specific immune cells, our study lays the groundwork for future research surrounding their use in cancer diagnostics and possibly in therapy. This could lead to improved strategies for tracking and altering the tumor environment as cancer progresses.
In our research, we developed a unique magnetic resonance imaging (MRI) probe composed of ultrafine iron oxide nanoparticles, which are small enough to avoid non-specific action in the body. We included a special peptide that actively seeks out M2 TAMs, allowing us to visualize them more clearly in mouse models of glioblastoma, a common and aggressive type of brain cancer.
The results were promising. The targeted nanoparticles showed a significant increase in accumulation within the tumors compared to standard nanoparticle formulations. This means that the M2-specific MRI probe provided a noticeable contrast in imaging, helping us differentiate areas of interest in the brain tumor environment better than conventional methods.
By demonstrating how effectively these iron nanoparticles can target specific immune cells, our study lays the groundwork for future research surrounding their use in cancer diagnostics and possibly in therapy. This could lead to improved strategies for tracking and altering the tumor environment as cancer progresses.
Read More
9
Iron influences glioblastoma treatment
Induction of Non-Canonical Ferroptosis by Targeting Clusters Suppresses Glioblastoma.
Moderate relevance due to methodology
We explored how iron metabolism could affect glioblastoma multiforme (GBM), a particularly aggressive form of brain tumor. Our study involved using a specialized gold cluster coated with a peptide designed to selectively target GBM cells. This material, called NA, efficiently delivered treatment both in lab settings and in living models.
A fascinating outcome emerged from our research: the introduction of NA sensitized GBM cells to a type of programmed cell death known as ferroptosis. Unlike apoptosis, ferroptosis can prove effective even in tumors that are resistant to conventional treatments. We traced the method behind this sensitization to the regulation of iron ion metabolism, which operates through what we identified as a non-canonical pathway of ferroptosis.
When combined with a ferroptosis inducer, NA significantly suppressed tumor growth in both a spheroid model and a mouse model, showcasing enhanced ferroptosis levels with commendable safety. Additionally, we observed a notable increase in the infiltration of tumor-fighting lymphocytes within the tumors. Therefore, NA represents a promising new approach for treating glioblastoma through the modulation of iron and ferroptosis.
A fascinating outcome emerged from our research: the introduction of NA sensitized GBM cells to a type of programmed cell death known as ferroptosis. Unlike apoptosis, ferroptosis can prove effective even in tumors that are resistant to conventional treatments. We traced the method behind this sensitization to the regulation of iron ion metabolism, which operates through what we identified as a non-canonical pathway of ferroptosis.
When combined with a ferroptosis inducer, NA significantly suppressed tumor growth in both a spheroid model and a mouse model, showcasing enhanced ferroptosis levels with commendable safety. Additionally, we observed a notable increase in the infiltration of tumor-fighting lymphocytes within the tumors. Therefore, NA represents a promising new approach for treating glioblastoma through the modulation of iron and ferroptosis.
Read More
8
Iron enhances brain tumor therapy
A Self-Cascading Catalytic Therapy and Antigen Capture Scaffold-Mediated T Cells Augments for Postoperative Brain Immunotherapy.
Combined treatments complicate results
We explored how iron treatment, combined with innovative scaffolding techniques, could enhance brain tumor therapy. The study introduced a unique implantable device known as the catalytic therapy and antigen capture scaffold (CAS) designed to target glioblastoma, one of the most aggressive brain tumors.
This CAS is made from 3D-printed materials that incorporate iron-based elements. Its role is to mimic natural processes within cancer cells, promoting the production of reactive oxygen species (ROS) that could help in the destruction of these cells. Alongside this, a drug called chloroquine was used to inhibit autophagy, which is a process that cancer cells often employ to protect themselves against treatment.
By trapping tumor-associated antigens, the CAS aims to improve the immune response against tumors by helping dendritic cells mature and activating T cells. As a result, we found that this method significantly enhanced immune activity against brain tumors after surgery. This suggests that iron, when used in conjunction with other therapies, can play an important role in boosting postoperative brain tumor immunotherapy and may lead to improved patient outcomes.
This CAS is made from 3D-printed materials that incorporate iron-based elements. Its role is to mimic natural processes within cancer cells, promoting the production of reactive oxygen species (ROS) that could help in the destruction of these cells. Alongside this, a drug called chloroquine was used to inhibit autophagy, which is a process that cancer cells often employ to protect themselves against treatment.
By trapping tumor-associated antigens, the CAS aims to improve the immune response against tumors by helping dendritic cells mature and activating T cells. As a result, we found that this method significantly enhanced immune activity against brain tumors after surgery. This suggests that iron, when used in conjunction with other therapies, can play an important role in boosting postoperative brain tumor immunotherapy and may lead to improved patient outcomes.
Read More
8
Innovative glioblastoma treatment approach
Metabolically-Driven Active Targeting of Magnetic Nanoparticles Functionalized with Glucuronic Acid to Glioblastoma: Application to MRI-Tracked Magnetic Hyperthermia Therapy.
Direct investigation of iron use
Our exploration of glioblastoma treatment revealed an innovative way to focus on this challenging brain tumor using iron-based nanoparticles. By functionalizing Iron Oxide Nanoparticles (IONPs) with glucuronic acid, we harnessed the natural glucose transporters that are often overactive in glioblastoma cells. This strategy allows for a direct pathway into the tumor, especially when we induce mild hypoglycemia to enhance the process.
The results of our preclinical study were promising, as we observed significant delays in tumor growth following treatment. The IONPs not only served to target the tumors effectively but also acted as agents for magnetic hyperthermia therapy, which provides an added layer of treatment. Using MRI tracking, we ensured that the procedure was not only effective but also precise, minimizing complications.
This approach shows great potential for developing new ways to tackle glioblastoma, marking a significant step forward in brain cancer treatment. The combination of advanced targeting methods and hyperthermia opens new doors for improved therapies, hopefully leading to more successful outcomes for patients.
The results of our preclinical study were promising, as we observed significant delays in tumor growth following treatment. The IONPs not only served to target the tumors effectively but also acted as agents for magnetic hyperthermia therapy, which provides an added layer of treatment. Using MRI tracking, we ensured that the procedure was not only effective but also precise, minimizing complications.
This approach shows great potential for developing new ways to tackle glioblastoma, marking a significant step forward in brain cancer treatment. The combination of advanced targeting methods and hyperthermia opens new doors for improved therapies, hopefully leading to more successful outcomes for patients.
Read More
8
Iron's role in glioblastoma therapy
Hydrogen sulfide-generating semiconducting polymer nanoparticles for amplified radiodynamic-ferroptosis therapy of orthotopic glioblastoma.
Limited specificity for iron effects
We explored the role of iron in the treatment of glioblastoma (GBM), a highly aggressive brain tumor. The study focused on a novel approach using hydrogen sulfide (HS)-generating semiconducting polymer nanoparticles combined with iron to amplify the therapeutic effects.
In an acidic tumor environment, these nanoparticles produced significant amounts of HS, which helped inhibit mitochondrial respiration and reduce cellular hypoxia. This combination promotes a unique cell death process known as ferroptosis, which is dependent on iron. Specifically, iron is reduced in the acidic tumor microenvironment by tannic acid, creating conditions that encourage tumor cell death.
While the findings indicate that incorporating iron enhances treatment effectiveness, it is essential to note that it works synergistically with other interventions, limiting our ability to pinpoint iron’s specific effects. Overall, our study underscores the potential of combining iron with innovative therapeutic strategies to combat glioblastoma more effectively.
In an acidic tumor environment, these nanoparticles produced significant amounts of HS, which helped inhibit mitochondrial respiration and reduce cellular hypoxia. This combination promotes a unique cell death process known as ferroptosis, which is dependent on iron. Specifically, iron is reduced in the acidic tumor microenvironment by tannic acid, creating conditions that encourage tumor cell death.
While the findings indicate that incorporating iron enhances treatment effectiveness, it is essential to note that it works synergistically with other interventions, limiting our ability to pinpoint iron’s specific effects. Overall, our study underscores the potential of combining iron with innovative therapeutic strategies to combat glioblastoma more effectively.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.3
6.3
Reduced symptoms
I developed restless legs syndrome (RLS) about 10 years ago and started taking it due to its relation to iron deficiency in the brain. My symptoms have since eased, but I haven't used it again as the lid was difficult to open, and I broke it.
